EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Completed · Phase 3 · Has a placebo group

Conditions studied: Heart Failure

In brief

This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction. Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine. Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.

Key facts

Study ID

NCT03057951

Run by

Boehringer Ingelheim

People needed

5988

Starts

2017-03-02

Expected to finish

2021-04-26

Last updated by the study team

2022-06-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patient, age >= 18 years at screening. For Japan only: Age >=20 years at screening
• Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association classification) class II-IV and preserved EF (Ejection Fraction)(LVEF (Left Ventricular Ejection Fraction) > 40 %) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide) > 300 pg/ml for patients without AF, OR > 900 pg/ml for patients with AF, analysed at the Central laboratory at Visit 1
• Structural heart disease within 6 months prior to Visit 1, OR documented HHF (Hospitalisation for Heart Failure) within 12 months prior to Visit 1
• Stable dose of oral diuretics, if prescribed
• Signed and dated written ICF (informed consent form)
• Further inclusion criteria apply

You may not qualify if…

• Myocardial infarction, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
• Heart transplant recipient or listed for heart transplant
• Acute decompensated HF (Heart Failure)
• Systolic blood pressure (SBP) >= 180 mmHg at Visit 2.
• Symptomatic hypotension and/or a SBP < 100 mmHg
• Indication of liver disease,
• Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) < 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration Equation))cr or requiring dialysis
• History of ketoacidosis
• Current use or prior use of a SGLT (Sodium-glucose co-transporter) -2 inhibitor or combined SGLT-1 and 2 inhibitor
• Currently enrolled in another investigational device or drug trial
• Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
• Women who are pregnant, nursing, or who plan to become pregnant while in the trial
• Further exclusion criteria may apply

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Heart Center Research, LLC — Huntsville, Alabama, United States
• University of California San Francisco — Fresno, California, United States
• La Mesa Cardiac Center — La Mesa, California, United States
• Purushotham, Akther & Roshan Kotha, MD Inc. — La Mesa, California, United States
• Long Beach Center for Clinical Research — Long Beach, California, United States
• VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
• Merced Vein and Vascular Center — Merced, California, United States
• Valley Clinical Trials, Inc. — Northridge, California, United States
• University of California Irvine — Orange, California, United States
• Covigilant Research, LLC — Riverside, California, United States
• University of California San Francisco — San Francisco, California, United States
• University of California — Torrance, California, United States
• Orange County Research Center — Tustin, California, United States
• Blue Coast Cardiology — Vista, California, United States
• South Denver Cardiology Associates, PC — Littleton, Colorado, United States
• Integrated Heart Care — Boca Raton, Florida, United States
• Southeast Clinical Research, LLC — Chiefland, Florida, United States
• Morton Plant Mease Health Care — Clearwater, Florida, United States
• Accel Research Sites — DeLand, Florida, United States
• Integrative Research Associates — Fort Lauderdale, Florida, United States
• Nature Coast Clinical Research — Inverness, Florida, United States
• East Coast Institute for Research, LLC — Jacksonville, Florida, United States
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
• Pinnacle Research Group, LLC — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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