Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables

Completed · Phase 3

Conditions studied: Anesthesia

In brief

During major surgical procedures, intravascular volume is maintained with the administration of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R. All three of these fluids are in common clinical use for this purpose. As large volumes of NS may result in a dilutional acidosis and an increasing base deficit, it may cloud clinical decision making when resuscitative efforts are guided by acid-base status on routine arterial blood gas analysis. This is a prospective, randomized study to evaluate changes in acid-base and electrolyte (sodium, potassium, calcium) status with the use of various isotonic fluids for intraoperative resuscitation.

Key facts

Study ID

NCT03054922

Run by

Nationwide Children's Hospital

People needed

59

Starts

2017-02-23

Expected to finish

2018-09-30

Last updated by the study team

2020-03-25

Who can join

Age: 10 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Major surgical procedure requiring arterial access

You may not qualify if…

• Comorbid disease process that contraindicates the use of any 1 of the 3 crystalloid solutions.

Where it is running

• Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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