Genetic Basis of Melanocytic Nevi

Recruiting now

Conditions studied: Melanocytic Nevi

In brief

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Key facts

Study ID

NCT03054584

Run by

University of California, Davis

People needed

50

Starts

2017-06-26

Expected to finish

2028-06-01

Last updated by the study team

2025-09-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects that are 18 years or older
• Subjects with melanocytic nevi\\

You may not qualify if…

• Patients less than 18 years of age
• Patients without melanocytic nevi
• Patients with a bleeding disorder or are taking anticoagulation medication

Where it is running

• University of California-Davis, Department of Dermatology — Sacramento, California, United States (enrolling)

Full record on ClinicalTrials.gov

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