Diagnostic Breath Analysis for Detection of Ventilator Acquired Pneumonia (VAP)

Completed

Conditions studied: Bacterial Infections

In brief

Breath samples from patients with Ventilator Acquired Pneumonia (VAP) will be analyzed to identify Volatile Organic Compounds (VOC) that have been specifically associated with VAP in previous animal models. Primary outcome measures will include the assessment of the zNose Diagnostic Breath Analysis System in the early detection of VOC's associated with VAP.

Key facts

Study ID

NCT03053258

Run by

Landon Pediatric Foundation

People needed

10

Starts

2016-10-01

Expected to finish

2019-02-01

Last updated by the study team

2019-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients ≥ 48 hours of ventilation with suspected VAP infection. Suspicion of VAP infection based on clinical evaluation criteria:
• Three or more positive out of the following:
• Tympanic temperature > 38 °C or < 35.5 °C
• Blood leukocytosis (10,000/µl)
• More than ten leukocytes in Gram stain of tracheal aspirate (in high-flow field)
• Positive culture of tracheal aspirate
• New, persistent, or progressive infiltrate on chest radiograph

You may not qualify if…

• Patients with pre-existing structural lung disease (COPD, asthma, lung cancer, etc.), thrombocytopenia (< 40,000/µL) and other coagulation abnormalities.

Where it is running

• Ventura County Medical Center — Ventura, California, United States

Full record on ClinicalTrials.gov

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