Safety and Efficacy of Selonsertib in Adults With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Nonalcoholic Steatohepatitis

In brief

The primary objective of this study is to evaluate whether selonsertib (SEL; GS-4997) can cause fibrosis regression and reduce associated complications in adults with cirrhosis due to NASH.

Key facts

Study ID

NCT03053063

Run by

Gilead Sciences

People needed

883

Starts

2017-01-30

Expected to finish

2019-05-06

Last updated by the study team

2020-05-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

Where it is running

• St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
• Mayo Clinic — Phoenix, Arizona, United States
• Baptist Medical Center — Little Rock, Arkansas, United States
• Arkansas Gastroenterology — North Little Rock, Arkansas, United States
• Southern California Research Center — Coronado, California, United States
• Fresno Clinical Research Center — Fresno, California, United States
• Scripps Clinical Research Services — La Jolla, California, United States
• University of California, San Diego (Altman Clinical and Translational Research Center) — La Jolla, California, United States
• Ruane Clinical Research Group — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Veterans Affair Greater Los Angeles Healthcare System, West Los Angeles VA Medical Center — Los Angeles, California, United States
• California Liver Research Institute — Pasadena, California, United States
• Huntington Medical Research Institutes (HMRI) Liver Center — Pasadena, California, United States
• Inland Empire Liver Foundation — Rialto, California, United States
• University of California, Davis Medical Center — Sacramento, California, United States
• Research and Education, Inc. — San Diego, California, United States
• Medical Associates Research Group — San Diego, California, United States
• Kaiser Permanente — San Diego, California, United States
• California Pacific Medical Center - Sutter Pacific Medical Foundation San Francisco Center for Liver Disease Dept. of Transplant — San Francisco, California, United States
• eStudySite — San Francisco, California, United States
• University of California, San Francisco-Liver Clinic — San Francisco, California, United States
• Island View Gastroenterology Associates- Ventura — Ventura, California, United States
• University of Colorado Denver and Hospital — Aurora, Colorado, United States
• South Denver Gastroenterology, PC — Englewood, Colorado, United States
• Institute of Liver Health — Chandler, Arizona, United States

Full record on ClinicalTrials.gov

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