Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C

Completed · Phase 2 · Has a placebo group

Conditions studied: Hypercholesterolemia

In brief

The purpose of this study is to determine if triplet therapy with bempedoic acid (ETC-1002) 180mg, ezetimibe 10mg, and atorvastatin 20mg is effective and safe versus placebo in patients with elevated LDL cholesterol.

Key facts

Study ID

NCT03051100

Run by

Esperion Therapeutics, Inc.

People needed

63

Starts

2017-01-19

Expected to finish

2017-07-05

Last updated by the study team

2020-04-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Fasting LDL-cholesterol between 130 - 189 mg/dL at screening following washout of all LDL-C-lowering drugs and nutritional supplements
• Men and nonpregnant, nonlactating women
• Sufficiently stable and suitable to undergo washout of all LDL-C-lowering drugs and nutritional supplements for 12 weeks

You may not qualify if…

• Fasting blood triglycerides greater than or equal to 400 mg/dL
• Body Mass Index (BMI) greater than 50 kg/m2
• History of clinically significant cardiovascular disease
• History of type 1 or type 2 diabetes

Where it is running

• PMG Research of Christie Clinic — Champaign, Illinois, United States
• PMG Research of Cary — Cary, North Carolina, United States
• PMG Research of Charlotte — Charlotte, North Carolina, United States
• Sensenbrenner Primary Care — Charlotte, North Carolina, United States
• PMG Research of Hickory — Hickory, North Carolina, United States
• PMG Research of Raleigh — Raleigh, North Carolina, United States
• PMG Research of Rocky Mount — Rocky Mount, North Carolina, United States
• PMG Research Salisbury — Salisbury, North Carolina, United States
• PMG Research of Wilmington — Wilmington, North Carolina, United States
• PMG Research of Charleston — Mt. Pleasant, South Carolina, United States
• Hampton Roads Center for Clinical Research — Virginia Beach, Virginia, United States

Full record on ClinicalTrials.gov

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