Breathing-Induced Myocardial Oxygenation Reserve

Completed

Conditions studied: Coronary Artery Disease

In brief

This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.

Key facts

Study ID

NCT03050346

Run by

McGill University Health Centre/Research Institute of the McGill University Health Centre

People needed

113

Starts

2016-01-01

Expected to finish

2022-03-24

Last updated by the study team

2022-10-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 y
• Informed consent as documented by signature (Appendix Informed Consent Form)
• Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia
• One-vessel or two-vessel CAD at coronary angiography (For healthy volunteers: absence of current or pre-existing cardiovascular and lung disease and absence of medication with cardiovascular effects)

You may not qualify if…

• General MRI contraindications (i.e pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy)
• Acute Coronary Syndrome (ACS) or other acute cardiac injury within 4 weeks
• Previous myocardial infarction, percutaneous coronary intervention or coronary artery bypass surgery
• Hemodynamically unstable conditions
• Significant or uncontrolled arrhythmias
• Lack of ability to follow commands
• Vasoactive medication (e.g. nitro or ß blockers) or nutrition with caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 h before the exam
• Non-ischemic cardiomyopathy
• Severe Pulmonary Disease

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States
• Jewish General Hospital — Montreal, Quebec, Canada
• McGill University Health Centre — Montreal, Quebec, Canada
• University Hospital Heidelberg — Heidelberg, Germany
• Groote Schuur Hospital — Cape Town, South Africa
• King's College London — London, United Kingdom

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.