Evaluating Treatment Resistant Dermatitis TaroIIR

Completed · Phase 4

Conditions studied: Atopic Dermatitis, Psoriasis

In brief

Psoriasis and atopic dermatitis are chronic inflammatory disease that account for a significant amount of patients in most dermatological practices. Topical corticosteroid agents are often prescribed for treatment of both these conditions, especially when they are localized rather than wide spread. The development of resistance to treatment is termed tachyphylaxis. Poor adherence, rather than down regulation of receptors, may be the primary cause of tachyphylaxis to topical corticosteroids. The primary objective of the study is to determine, under conditions designed to assure good adherence, whether topical 0.25% desoximetasone spray improves clinical outcomes in patients who have resistant inflammatory skin disease defined by failure of previous topical steroid treatment.

Key facts

Study ID

NCT03050294

Run by

Wake Forest University Health Sciences

People needed

24

Starts

2017-02-01

Expected to finish

2017-06-01

Last updated by the study team

2020-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female ≥18 years of age at baseline visit.
• Documentation of plaque-type psoriasis or atopic dermatitis diagnosis as evidenced by one or more clinical features
• Written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study

You may not qualify if…

• Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
• Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
• No access to a phone throughout the day
• Subject is diagnosed with a disease that is known to effect adherence and would otherwise bias our results (Such as Alzheimer's or dementia)
• Patient had a history of allergy or sensitivity to corticosteroids or history of any drug hypersensitivity or intolerance that, in the opinion of the Investigator, would compromise the safety of the patient or the results of the study.

Where it is running

• Wake Forest University Health Sciences Department of Dermatology — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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