Hypoxemia in Maintenance Hemodialysis Patients
Status unconfirmed
Conditions studied: Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis, Kidney Failure, Chronic
In brief
Previous research has shown that many patients with kidney failure undergoing chronic hemodialysis (HD) have a very low venous oxygen concentration, which may further decrease during dialysis treatments. This may be due to a variety of factors including anemia, compromised pulmonary function, and chronic fluid volume overload. Previous studies have shown that low venous oxygen concentrations may increase the risk of cardiovascular events, cognitive deficits, and mortality in HD patients. The purpose of this study is to identify patients with hypoxemia during HD treatments and characterize the extent of and implications of their hypoxemia. Specifically, the investigators aim to examine the relationship between central venous oxygen concentration and hemodynamic changes during dialysis treatment. The investigators will evaluate the relationship between cardiac output as measured by the Task Force Monitor and central venous oxygen saturation as measured by the Crit-Line Monitor and Wrist0x2 in HD patient. Data from this study will provide insight into potential mechanisms responsible for side effects associated with dialysis treatment, such as drops in blood pressure and cognitive dysfunction.
Key facts
- Study ID
- NCT03045796
- Run by
- University of Illinois at Urbana-Champaign
- People needed
- 15
- Starts
- 2017-03-01
- Expected to finish
- 2018-01-01
- Last updated by the study team
- 2017-05-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18 years and able to give written informed consent to the study
- Central Venous Catheter (CVC) used for vascular access
- Participants must receive hemodialysis treatment at least 3 days per week.
- Participants must be on hemodialysis treatment longer than 3 months. Patients on dialysis treatment for < 3 months will be excluded, or have their enrollment postponed, due to physiological changes that typically occur at the onset of dialysis.
- Participants must have a central-venous catheter as their vascular access site for dialysis, as our aim is to measure venous oxygen concentrations. Patients with A-V fistula's or grafts will be excluded because we are not interested in collecting arterial oxygen concentrations.
You may not qualify if…
- Scheduled renal transplantation during the study
- Active infection requiring ongoing antibiotics or antivirals
- Simultaneous participation in another clinical study with potential impact on cardiovascular/hemodynamic parameters
Where it is running
- University of Illinois at Urbana-Champaign — Urbana, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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