ADAPT - A Patient Registry of the Real-world Use of Orenitram®

Running, not enrolling

Conditions studied: Pulmonary Arterial Hypertension

In brief

This prospective, observational, multicenter, patient registry will follow patients who are receiving treatment with Orenitram for the treatment of PAH for up to 78 weeks from Orenitram initiation

Key facts

Study ID

NCT03045029

Run by

United Therapeutics

People needed

300

Starts

2017-07-18

Expected to finish

2027-03-01

Last updated by the study team

2026-04-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients are eligible for the registry if:
• The patient voluntarily gives informed consent to participate in the study.
• The patient must be at least 18 years of age or older.
• The patient is prescribed Orenitram (per the package insert indication), and plans to initiate therapy with this medication or has been receiving Orenitram for 182 or fewer days.
• The patient agrees to dosing, prostacyclin-related AE of interest record keeping, survey participation during designated time periods, and recording any medication changes, use, for the duration of the study.
• The patient has the ability to answer surveys and use the diary in English.
• The patient must have an email address and be willing to access the PRO Portal.

You may not qualify if…

• Patients are ineligible for the registry if:
• The patient has previously received Orenitram for more than 182 days.
• The patient is currently participating in an investigational drug or device study or has participated in a clinical study with an investigational product other than Orenitram in PAH within

Where it is running

• University of California - San Francisco — Fresno, California, United States
• University of Southern California - Keck Medical Center — Los Angeles, California, United States
• Paloma Medical Group — San Juan Capistrano, California, United States
• Santa Barbara Pulmonary Associates — Santa Barbara, California, United States
• Harbor UCLA Medical Center — Torrance, California, United States
• Aurora Denver Cardiology Associates — Aurora, Colorado, United States
• Pueblo Pulmonary Associates — Pueblo, Colorado, United States
• Lung Associates PA — Bradenton, Florida, United States
• University of Florida Clinical Research Center — Gainesville, Florida, United States
• St. Vincent's Lung, Sleep, and Critical Care Specialists — Jacksonville, Florida, United States
• AdventHealth Orlando — Orlando, Florida, United States
• Central Florida Pulmonary Group, P.A. — Orlando, Florida, United States
• USF South Florida Heart Health — Tampa, Florida, United States
• Cleveland Clinic Florida — Weston, Florida, United States
• Piedmont Healthcare/Research — Austell, Georgia, United States
• Loyola University Chicago — Chicago, Illinois, United States
• Saint Vincent Hospital and Health Services — Indianapolis, Indiana, United States
• University Of Iowa Hospital and Clinics — Iowa City, Iowa, United States
• University of Louisville Physicians Outpatient Center — Louisville, Kentucky, United States
• Chest Medicine Associates — South Portland, Maine, United States
• Mclaren Greater Lansing — Okemos, Michigan, United States
• Beaumont Hospital Troy — Troy, Michigan, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• Albany Medical College — Albany, New York, United States
• New York Methodist Hospital — Brooklyn, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.