Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
Completed · Not applicable
Conditions studied: Cognitive Impairment, Depression
In brief
The present collaborative R01 study, between Cornell and Johns Hopkins, aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs. Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in improving cognitive, affective, and functioning outcomes.
Key facts
- Study ID
- NCT03043573
- Run by
- Weill Medical College of Cornell University
- People needed
- 80
- Starts
- 2017-07-01
- Expected to finish
- 2024-09-19
- Last updated by the study team
- 2025-08-12
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Amnestic MCI as defined by Albert et al
- Montgomery Asberg Depression Rating Scale (MADRS) greater than 7 and MADRS total less than 30
- Participants will be off antidepressants, cholinesterase inhibitors or memantine, or on a stable dosage for at least 12 weeks without any medical recommendation to adjust dosage in next 3 months (during treatment)
- Clinical Dementia Rating (CDR) = 0.5 at screening
- Subjects will have capacity to consent
You may not qualify if…
- Deemed to have a significant suicide risk as assessed by site PI and clinical team
- Deemed too unstable medically or neurologically to safely enroll in a research trial
- Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy. Requiring psychiatric hospitalization at baseline for safety.
- Current involvement in psychotherapy
- Lack of English fluency
Where it is running
- Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
- Weill Cornell Medicine — New York, New York, United States
- Montefiore Medical Center — The Bronx, New York, United States
- Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine — White Plains, New York, United States
Full record on ClinicalTrials.gov
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