Intestinal Permeability and Endometriosis

Completed

Conditions studied: Endometriosis

In brief

The objective of this project will be to determine whether patients with a surgical diagnosis of endometriosis have impaired intestinal permeability as compared with healthy controls. This would suggest the presence of an environmentally triggered and intestinally mediated association in the etiology of endometriosis. This would be a proof of concept trial to establish whether there is in fact a relationship worthy of future research.

Key facts

Study ID

NCT03042923

Run by

University of Tennessee

People needed

46

Starts

2016-04-01

Expected to finish

2019-06-01

Last updated by the study team

2020-04-28

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female patients with documented history of pelvic pain for the study arm.
• Healthy female controls without history consistent with autoimmune disease or pelvic pain

You may not qualify if…

• Co-morbid autoimmune disease such as Celiac disease, lupus, ankylosing spondylitis, alcoholism and diabetes which have been shown to exhibit elevated levels of Zonulin and therefore impaired intestinal permeability. Drinking alcohol and taking NSAIDS elevate intestinal permeability and would affect data.

Where it is running

• Erlanger Medical Center — Chattanooga, Tennessee, United States
• Women's Surgery Center — Chattanooga, Tennessee, United States

Full record on ClinicalTrials.gov

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