Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery

Status unconfirmed · Early Phase 1

Conditions studied: Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection

In brief

This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery. Polyethylene glycol, may draw water from the body into the colon, flushing out the contents of the colon. Antibiotics, like neomycin and metronidazole hydrochloride, may stop bacteria from growing. It is not yet known whether it's better to give preoperative neomycin and metronidazole hydrochloride with or without polyethylene glycol in reducing surgical site infection after colorectal surgery.

Key facts

Study ID

NCT03042091

Run by

Thomas Jefferson University

People needed

224

Starts

2016-09-01

Expected to finish

2021-10-01

Last updated by the study team

2018-08-22

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing ileocolic resections, partial and total colectomies, and rectal resections for neoplasm, inflammatory bowel disease, or diverticulitis
• Subjects with the mental capacity to give informed consent

You may not qualify if…

• Patients undergoing emergent colorectal resections
• Patients who are decisionally-impaired and lack the mental capacity to give informed consent

Where it is running

• Thomas Jefferson University — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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