Decreasing Antibiotic Use in Infants With Suspected Ventilator-associated Infection

Completed

Conditions studied: Ventilator Associated Pneumonia, Nosocomial Infections in Children, Microbial Colonization

In brief

This is a prospective study with three specific aims: (1) To convene a consensus conference to develop a guideline for antibiotic use in infants (age \< 3 yrs) with suspected ventilator-associated infection; (2) To evaluate outcomes before and after implementation of the antibiotic guideline; (3) To evaluate changes in the tracheal microbiome over the course of mechanical ventilation

Key facts

Study ID

NCT03041207

Run by

Virginia Commonwealth University

People needed

555

Starts

2017-03-20

Expected to finish

2019-04-30

Last updated by the study team

2019-07-17

Who can join

Age: any, up to 3. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age newborn -- 3 years in the Pediatric ICU
• on invasive mechanical ventilation > 48 hours
• evaluation for ventilator-associated infection that includes respiratory secretion cultures and microscopic evaluation of the gram-stained specimen
• antibiotics initiated for suspected ventilator-associated or other infection

You may not qualify if…

• Immune compromise --Other positive cultures (blood, urine, etc.) for which antibiotic continuation is appropriate

Where it is running

• Banner University Medical Center — Tucson, Arizona, United States
• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• Children's Hospital of Los Angeles — Los Angeles, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• University of Miami Health System - Holtz Children's Hospital — Miami, Florida, United States
• Children's Healthcare of Atlanta - Egleston Hospital — Atlanta, Georgia, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Hospital for Children at Indiana University Health — Indianapolis, Indiana, United States
• C.S. Mott Children's Hospital — Ann Arbor, Michigan, United States
• Helen DeVos Children's Hospital — Grand Rapids, Michigan, United States
• St. Louis Children's Hospital - Washington University — St Louis, Missouri, United States
• Children's Hospital of Buffalo — Buffalo, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• University Hospitals Rainbow Babies & Children's Hospital — Cleveland, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Penn State Children's Hospital — Hershey, Pennsylvania, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of Richmond at VCU — Richmond, Virginia, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States
• Centre hospitalier universitaire Sainte-Justine — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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