Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects
Completed · Not applicable · Has a placebo group
Conditions studied: Nasal Allergy
In brief
The purpose of this study is to see if the recruitment of a certain cell type (the alpha 4 integrin (CD49d) expressing neutrophil) during a nasal allergen challenge can be inhibited by pretreatment with an FDA approved leukotriene antagonist (montelukast).
Key facts
- Study ID
- NCT03039101
- Run by
- Mitchell Grayson
- People needed
- 25
- Starts
- 2017-09-06
- Expected to finish
- 2018-07-16
- Last updated by the study team
- 2019-10-07
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 21 - 65 years of age, inclusive
- A personal history of allergic rhinitis (hayfever) (by self-report)
- At least one positive skin test to cat, dust mite mix, Timothy grass, Bermuda grass, Bluegrass, or Ragweed
- Ability to provide informed consent
- Willingness to undergo epicutaneous skin testing
- Willingness to undergo nasal lavages and nasal allergen challenges
- Willingness to undergo 2 peripheral blood draws (10 cc each)
You may not qualify if…
- Use of systemic antihistamine in the past 5 days
- Use of intranasal corticosteroids or intranasal antihistamines currently or in the past 2 weeks
- Use of Montelukast currently or in the past week
- Hypersensitivity or allergy to Montelukast
- Inability to perform/undergo any study procedures
- Pregnancy (by subject report) or breastfeeding
- Confirmed or suspected immunodeficiency
- Persistent asthma, atopic dermatitis, or any other co-morbid disease except for allergic rhinitis
- Any symptoms of asthma in the past 2 weeks (shortness of breath, wheezing, and/or use of albuterol)
- Fever (temperature over 99F) currently or in the past 2 weeks
- Current or previous use of a biologic or investigational agent in the past 6 months
- Current or past suicidal thoughts/attempts
Where it is running
- Nationwide Children's Hospital — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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