Etiology of Eczema Herpeticum (EH)

Completed

Conditions studied: Eczema Herpeticum

In brief

Atopic dermatitis, also called eczema, is a disease with dry, scaly, itchy skin. Those with atopic dermatitis may have complications from skin infections such as eczema herpeticum after herpes simplex virus (HSV) infection. Symptoms of eczema herpeticum include fever and clusters of itchy blisters which crust over and form sores. Although exposure to HSV is widespread, most people clear the virus and only a subset of individuals with atopic dermatitis develop eczema herpeticum. The purpose of this study is to determine why some individuals with atopic dermatitis are at higher risk for recurrent skin infections with HSV. The study team will compare how people with atopic dermatitis with a history of recurrent eczema herpeticum, people with atopic dermatitis without a history of eczema herpeticum, and people without atopic dermatitis respond to HSV.

Key facts

Study ID

NCT03038932

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

69

Starts

2017-02-22

Expected to finish

2020-11-24

Last updated by the study team

2021-01-14

Who can join

Age: 3 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be a participant already enrolled in the ADRN Registry and provided DNA (ClinicalTrials.gov ID: NCT01494142);
• Participant and/or parent guardian must be able to understand and provide informed consent;
• A history of Atopic Dermatitis (AD) with a history of eczema herpeticum (ADEH+), as diagnosed using the Atopic Dermatitis Research Network (ADRN) Standard Diagnostic Criteria, with ≥3 episodes of Eczema Herpeticum (EH)
• OR
• A history of AD without a history of eczema herpeticum (ADEH-), as diagnosed using the ADRN Standard Diagnostic Criteria, and no immediate family members (mother, father, full siblings, half-siblings, offspring, aunts, uncles, cousins, or grandparents) with a history of EH
• OR
• Non-atopic as diagnosed using the ADRN Standard Diagnostic Criteria.
• Anti-Herpes Simplex Virus (HSV)-1 or Anti-HSV-2 Immunoglobulin G (IgG) seropositive.

You may not qualify if…

• Inability or unwillingness of a participant and/or parent guardian to give written informed consent or comply with study protocol;
• Pregnant or lactating women;
• Known or suspected immunosuppression;
• Severe concomitant illness(es);
• History of keloid formation (adults only);
• History of lidocaine or Novocain allergy (adults only);
• History of serious life-threatening reaction to latex, tape, or adhesives;
• Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
• Use of biologics within 5 half-lives (if known) or 16 weeks of the Screening Visit;
• Use of an investigational drug within 5 half-lives (if known) or 8 weeks of the Screening Visit.

Where it is running

• National Jewish Health: Division of Pediatric Allergy and Clinical Immunology — Denver, Colorado, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.