Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS

Status unconfirmed

Conditions studied: Acute Respiratory Distress Syndrome, Neuromyopathies

In brief

The proposed work will determine the effect of neuromuscular blockade on physical function and recovery in patients with ARDS. The investigators will conduct a prospective ancillary study at five PETAL clinical centers that will evaluate the neuromuscular structure and function of ROSE (Reevaluation of Systemic Early Neuromuscular Blockade) patients during and after critical illness, including in-person assessments at 6 months after hospital discharge. The investigators hypothesize that patients randomized to NMB will have an increase in ICU-acquired neuromuscular dysfunction during and after critical illness.

Key facts

Study ID

NCT03038906

Run by

University of Washington

People needed

290

Starts

2017-01-01

Expected to finish

2020-09-01

Last updated by the study team

2017-02-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be enrolled in the PETAL Network's ROSE study
• Patients must have at least one complete leg

You may not qualify if…

• Complete spinal cord injury with deficits at level T1 or above
• Severe peripheral neuromuscular disease (specifically motor neuron disease (ALS) or acute Guillain-Barre Syndrome)
• Inability to obtain informed consent

Where it is running

• University of Washington — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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