DCM Precision Medicine Study

Running, not enrolling · Not applicable

Conditions studied: Idiopathic Dilated Cardiomyopathy

In brief

The aims of the DCM Precision Medicine Study are to test the hypothesis that DCM has substantial genetic basis and to evaluate the effectiveness of a family communication intervention in improving the uptake and impact of family member clinical screening.

Key facts

Study ID

NCT03037632

Run by

Ray Hershberger

People needed

6500

Starts

2016-06-07

Expected to finish

2026-06-30

Last updated by the study team

2025-07-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meeting criteria for dilated cardiomyopathy (DCM) :
• Left ventricular ejection fraction <50%
• Left ventricular enlargement (A left ventricular end-diastolic dimension > 95%tile population standard based on gender and height).
• Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic DCM)
• Any age (including children)
• Non-Hispanic and Hispanic ethnicity
• All races (PI pre-approval required for recruitment beyond pre-specified recruitment targets).
• Ability to give informed consent
• Ability to communicate in English (except Spanish language at sites approved to recruit individuals of Hispanic ethnicity)
• Willingness to participate in a family-based study (patient willing to work with a clinical site and/or OSU to facilitate the recruitment and enrollment of family members to the study).

You may not qualify if…

• Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any major epicardial coronary artery)
• Primary valvular disease
• Adriamycin or other cardiotoxic drug exposure
• Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
• Congenital heart disease
• Other detectable causes of dilated cardiomyopathy, including sarcoid and hemochromatosis.
• Other active multi-system disease that may cause DCM (e.g., active connective tissue disease).
• Severe and untreated or untreatable hypertension (systolic blood pressures routinely greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if resistant to multidrug treatment).
• However, conventional risk factors for DCM, including obesity, routinely treated hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular noncompaction, will NOT be considered exclusion criteria.

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of Arizona Sarver Heart Center — Tucson, Arizona, United States
• Cedars-Sinai Medical Center — Beverly Hills, California, United States
• UCLA Medical Center — Los Angeles, California, United States
• Stanford University — Palo Alto, California, United States
• Medstar Washington Hospital Center (DC) — Washington D.C., District of Columbia, United States
• South Miami Heart Center — Miami, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Louisiana State University Health Sciences Center in New Orleans — New Orleans, Louisiana, United States
• University of Maryland — Baltimore, Maryland, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Washington University in St. Louis — St Louis, Missouri, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• NYU School of Medicine — New York, New York, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• Houston Methodist Hospital — Houston, Texas, United States
• University of Utah — Salt Lake City, Utah, United States
• Inova Heart and Vascular Institute — Fairfax, Virginia, United States

Full record on ClinicalTrials.gov

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