Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Key facts

Study ID

NCT03037216

Run by

Joslin Diabetes Center

People needed

10

Starts

2016-12-15

Expected to finish

2020-02-01

Last updated by the study team

2020-08-20

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%

You may not qualify if…

• Age <18 and >50
• HbA1c ≥ 5.7%; heart or lung disease
• acute systemic infection accompanied by fever, body aches, or swollen lymph glands
• BMI > 27 kg/m2
• current dieting or weight loss efforts
• current pregnancy or breastfeeding
• known history of HIV/AIDS; cancer
• biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
• recent blood donation
• clinical history of stroke
• hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
• type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
• Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing

Where it is running

• Joslin Diabetes Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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