Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS
Completed · Not applicable · Has a placebo group
Conditions studied: Gulf War Syndrome, Headache
In brief
This study aims to assess the effect of repetitive transcranial magnetic stimulation (rTMS) on Gulf War illness related headaches and pain.
Key facts
- Study ID
- NCT03030794
- Run by
- Veterans Medical Research Foundation
- People needed
- 90
- Starts
- 2016-12-01
- Expected to finish
- 2019-06-01
- Last updated by the study team
- 2020-01-18
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male or female between ages 18-65
- CDC Criteria for GWI
- Kansas Criteria for GWI
- International Headache Society Criteria for Migraine HA w/o aura
- Average Headache Exacerbation Intensity >3 on 0-10 NPRS
- Average Overall Daily Muscle Pain Intensity >3 on 0-10 NPRS
- Average Overall Daily Extremities Joint Pain Intensity >3 on 0-10 NPRS
- Headache Exacerbation/Attack ≥ 3 times/week, lasting >4 hrs in past 3 months
You may not qualify if…
- Pregnancy
- History of pacemaker implant
- Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
- History of dementia, major psychiatric diseases, or life threatening diseases
- Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
- History of seizure
- Pending litigation
- Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
- Lack of ability to understand the experimental protocol and to adequately communicate in English
- History of Traumatic Brain injury
- Chronic Tension or Cluster Headache
- Ongoing Cognitive Rehabilitation or Treatment of PTSD
- Criteria for healthy veterans without Gulf War Illness headaches and pain:
- Inclusion Criteria:
- Male or female between ages 18-65
- Served at least 30 consecutive days in the Persian Gulf between 8/90-7/91
- Exclusion Criteria:
- CDC Criteria for GWI
- Kansas Criteria for GWI
- International Headache Society Criteria for Migraine HA w/o aura
- Average Headache Exacerbation Intensity >3 on 0-10 NPRS
- Average Overall Daily Muscle Pain Intensity >3 on 0-10 NPRS
- Average Overall Daily Extremities Joint Pain Intensity >3 on 0-10 NPRS
- Headache Exacerbation/Attack ≥ 3 times/week, lasting >4 hrs in past 3 months
- Pregnancy
Where it is running
- Naval Medical Center San Diego — San Diego, California, United States
- Veteran Affairs Hospital — San Diego, California, United States
Full record on ClinicalTrials.gov
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