Corneal Elastography and Patient Specific Modeling

Recruiting now

Conditions studied: Cornea; Ectasia, Refractive Errors, Keratoconus

In brief

The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. One aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.

Key facts

Study ID

NCT03030755

Run by

The Cleveland Clinic

People needed

60

Starts

2016-05-01

Expected to finish

2027-05-01

Last updated by the study team

2026-06-03

Who can join

Age: 16 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus.
• Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery.

You may not qualify if…

• Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available).

Where it is running

• Cleveland Clinic Foundation Cole Eye Institute — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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