A Phase 1b Study of OMP-305B83 Plus Paclitaxel in Subjects With Ovarian, Peritoneal or Fallopian Tube Cancer

Completed · Phase 1

Conditions studied: Cancer Ovaries, Cancer Peritoneal, Cancer, Fallopian Tube

In brief

The purpose of this study is to test the efficacy and safety of an experimental drug, OMP-305B83, when given in combination with paclitaxel. OMP-305B83 is a humanized monoclonal antibody and was developed to target cancer stem cells. Based on preclinical studies, it is believed that OMP-305B83 may block the growth of cancer stem cells and may also impair the productive growth of new blood vessels, which tumors need to grow and spread.

Key facts

Study ID

NCT03030287

Run by

OncoMed Pharmaceuticals, Inc.

People needed

44

Starts

2016-12-01

Expected to finish

2020-04-01

Last updated by the study team

2020-09-03

Who can join

Age: 21 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Platinum resistant Grade 2 or 3 ovarian, primary peritoneal or fallopian tube cancer
• Measureable disease per response evaluation criteria (RECIST) v1.1
• Prior bevacizumab
• Age > or = 21 years
• Adequate organ and marrow function
• For women of childbearing potential and men with partners of childbearing potential, agreement (by patient and/or partner) to use two effective forms of contraception from study entry through at least 6 months after the termination visit.
• Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

• Treatment with any anti-cancer therapy, including radiotherapy, chemotherapy, biologic therapy. Prior therapy with weekly paclitaxel for recurrent disease, unless administered more than 2 years prior to enrollment, unless part of an upfront treatment strategy.
• History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, clinical signs or symptoms of gastrointestinaI obstruction or other known clinically signification gastrointestinal disease.
• Subjects with brain metastases
• Subjects with leptomeningial disease or neoplasms in the last 5 years
• Blood pressure >140/80
• Significant intercurrent illness that will limit the patient's ability to participate in the study
• Subjects with known metastases that are currently involving the lumen of the gastrointestinal tract.
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to enrollment, or anticipation of need for major surgical procedure during the course of the study
• Pregnant or nursing women
• New York Heart Association Classification II, III, or IV
• Inability to comply with study and follow up procedure

Where it is running

• University of Colorado, Anschutz Medical Campus — Aurora, Colorado, United States
• H. Lee Moffitt Cancer Center & Research Institute, Inc. (Moffitt Cancer Center) — Tampa, Florida, United States
• Levine Cancer Institute — Charlotte, North Carolina, United States
• Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
• The University of Pennsylvania Health System — Philadelphia, Pennsylvania, United States
• Tennessee Oncology, PLLC — Nashville, Tennessee, United States
• The University of Texas, MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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