Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas

Stopped early · Phase 2

Conditions studied: Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents

In brief

This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.

Key facts

Study ID

NCT03029104

Run by

Cxlusa

People needed

2228

Starts

2016-12-21

Expected to finish

2020-12-27

Last updated by the study team

2022-01-12

Who can join

Age: 8 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of at least one of the following conditions:
• Keratoconus
• Forme fruste keratoconus
• Post-LASIK ectasia
• Pellucid marginal degeneration
• Forme fruste pellucid marginal degeneration
• Diurnal fluctuation post-radial keratotomy
• Terrien's marginal degeneration

You may not qualify if…

• Corneal thickness < 375 microns measured by ultrasound or Pentacam.
• Contraindications or hypersensitivities to any study medications or their components.
• Pregnancy or breastfeeding.
• Any history of herpes simplex corneal disease in an eye to be treated.
• Nystagmus or any other condition that would, in the judgement of the investigator, prevent a steady gaze during the treatment.
• Inability to cooperate with diagnostic tests.
• Enrollment in another ophthalmic clinical trial.

Where it is running

• Schwartz Laser Eye Center — Scottsdale, Arizona, United States
• Goodman Eye Center — San Francisco, California, United States
• Cornea Consultants of Colorado — Littleton, Colorado, United States
• Woolfson Eye Institute — Atlanta, Georgia, United States
• Chicago Cornea Consultants — Chicago, Illinois, United States
• Chicago Cornea Consultants, Ltd. — Hoffman Estates, Illinois, United States
• Ophthalmology Associates — St Louis, Missouri, United States
• Cleveland Eye Clinic — Brecksville, Ohio, United States
• Cornea Associates of Texas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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