pH-weighted MRI in Multiple Sclerosis: A Surrogate Marker of Tissue Metabolic Stress
Completed
Conditions studied: Multiple Sclerosis
In brief
Twenty subjects (10 patients and 10 age-matched control volunteers) will be recruited for this study. MRI scans will take place on a 3T MRI Scanner (Skyra or Prisma, Siemens Medical Solutions) located at The NYU Center for Biomedical Imaging. MRI scans will consist of a 1-hour brain scan for both patients and controls. In the first 6 months of the study, investigators will develop and test a uMT-based APT imaging for brain tissue pH measurement and use a hypercapnia paradigm to validate the tissue pH changes between breathing room air and 5% CO2 (by increasing tissue acidity) inhalation. With implementation of hypercapnia MRI, pH-weighted imaging will be validated for its robustness and reproducibility.
Key facts
- Study ID
- NCT03028675
- Run by
- NYU Langone Health
- People needed
- 4
- Starts
- 2017-05-01
- Expected to finish
- 2018-08-10
- Last updated by the study team
- 2020-07-13
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy male or female non-MS control volunteers
You may not qualify if…
- Medically unstable or with cardiac, pulmonary, hematological, renal, or hepatic dysfunction.
- Current or past DSM-IV diagnosis of major depression, bipolar and psychotic disorders.
- Contraindications for MRI, including
- Intracranial clips
- Metal implants
- External metallic devices/objects/clips within 10mm of the head
- Suspected or confirmed metal in the eyes (history of welding or similar activity)
- Claustrophobia
- Cardiac pacemaker or pacing wires
- Pregnancy - Pregnancy tests will be offered to women of childbearing age at no cost to the subject
- History of moderate to severe head injury, stroke, and seizures.
- Alcoholism or drug dependency.
- Renal or liver disease as this may cause concerns related to Gd-DTPA contrast agent.
- Allergy to the contrast agent Gadolinium
- Relapses or steroid therapy in patient at or in the month preceding the study
- Patients only
Where it is running
- New York University School of Medicine — New York, New York, United States
Full record on ClinicalTrials.gov
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