Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)

Stopped early · Not applicable

Conditions studied: Apraxia Speech

In brief

The purpose of this study is to assess the influence of transcranial magnetic stimulation (TMS) on speech performance in individuals with primary progressive apraxia of speech.

Key facts

Study ID

NCT03028324

Run by

University of Miami

People needed

4

Starts

2017-08-09

Expected to finish

2018-11-13

Last updated by the study team

2020-05-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ages 18 and above who are able to consent
• Diagnosis of primary progressive apraxia of speech based on neurological evaluation

You may not qualify if…

• Any uncontrolled medical condition expected to limit life expectancy or interfere with participation in the trial (i.e. unstable cancer, severe depression or anxiety by DSM-IV criteria)
• Abnormal stress test, as determined by the treating physician (unless cardiology clearance provided)
• Active substance abuse or alcohol dependence
• Uncorrected vision or hearing deficits that would preclude administration of the cognitive measures
• Unwilling or unable to provide written informed consent
• History of fainting spells of unknown or undetermined etiology that might constitute seizures
• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
• No medication is an absolute exclusion from TMS. Medications will be reviewed by the responsible MD and a decision about inclusion will be made based on the following:
• The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
• The published TMS guidelines review medications to be considered with TMS
• Any metal in the brain, skull or elsewhere unless approved by the responsible MD
• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD
• Substance abuse or dependence within the past six months
• Absence of corticospinal functional integrity

Where it is running

• University of Miami Miller School of Medicine — Miami, Florida, United States

Full record on ClinicalTrials.gov

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