Self-Face Recognition After Face Transplantation
Completed · Not applicable
Conditions studied: Disfigurement of Face
In brief
The purpose of the proposed study is to use functional magnetic resonance imaging (fMRI) to investigate how a change in facial appearance is initially represented in brain circuits and then alters over time, as the new face becomes recognized as "me". Investigators will try to identify areas of the brain responsible for processing and storing information about self-facial recognition; Examine how these areas of the brain respond to images of "self" and "non-self" and; Investigate how the brain responds, over time, to changes in facial recognition, particularly at time points: i) prior to facial injury, ii) post-injury but prior to facial transplantation, and iii) after receiving facial transplantation.
Key facts
- Study ID
- NCT03027141
- Run by
- NYU Langone Health
- People needed
- 4
- Starts
- 2017-02-01
- Expected to finish
- 2025-12-10
- Last updated by the study team
- 2026-02-27
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who have suffered from severe facial disfigurement which warrant facial transplantation and have been evaluated and approved for transplantation, will be included.
You may not qualify if…
- Must be be able to enter and be scanned using MRI.
- Able to give full informed consent, before each scan and throughout their time in which they are participating in the study
- Able to perform the task to a high standard and also to have no underlying conditions that may alter how they process pictures of face
- Participants must have none of the following, which cannot safely be removed without risk or discomfort while they enter the MRI unit:
- a pacemaker
- metal implants
- metal that cannot be removed on their body (e.g. shrapnel, piercings)
- metal clips
- an artificial heart valve
- a cochlear implant
- drug patches
- a contraceptive coil
- dental plates/braces with metal in
- hearing aids
- Participants will also be excluded on the grounds of safety and comfort inside the MRI scanner if they have one of the following underlying conditions
- epilepsy
- diabetes
- heart disease
- thermoregulatory problems (problems regulating body temperature)
- a possibility of being pregnant
- currently breastfeeding
- Participants will also be excluded on the grounds of MRI data quality for the following reasons:
- history of mental illness
- claustrophobia (discomfort in confined spaces)
- Neurological conditions
Where it is running
- New York University School of Medicine — New York, New York, United States
Full record on ClinicalTrials.gov
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