Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation

Completed · Phase 4

Conditions studied: Acute Respiratory Failure, Intubation Complication

In brief

Endotracheal intubation is common in the care of critically ill patients. Complications of airway management in this setting are frequently encountered and may be associated with an increased risk of death. The prevention of complications during urgent and emergent endotracheal intubation is a key focus for airway management research. Post-intubation hypotension (PIH), a common complication of endotracheal intubation in the critically ill, may be prevented by a bolus of intravenous fluid prior to the start of the procedure, but this approach has not been examined in a prospective trial. There are no randomized trials of intravenous fluid administration to prevent PIH in critically ill adults. The investigators propose a randomized trial of fluid loading to prevent PIH in critically ill adults.

Key facts

Study ID

NCT03026777

Run by

Louisiana State University Health Sciences Center in New Orleans

People needed

337

Starts

2017-01-01

Expected to finish

2018-01-01

Last updated by the study team

2021-01-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is admitted to participating study unit
• Planned procedure is endotracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
• Administration of sedation with or without neuromuscular blockade is planned
• Age ≥ 18 years old

You may not qualify if…

• Operator believes fluid loading to be absolutely indicated or contraindicated for the safe care of the patient
• Urgency of intubation precludes safe performance of study procedures
• Pregnancy
• Prisoners
• Age < 18 years old

Where it is running

• University of Alabama Birmingham — Birmingham, Alabama, United States
• Ochsner Medical Center — Jefferson, Louisiana, United States
• LSUHSC and University Medical Center — New Orleans, Louisiana, United States
• Lahey Medical Center — Burlington, Massachusetts, United States
• Lincoln Medical Center — The Bronx, New York, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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