Lactate Acidosis in Postoperative Hearts
Completed
Conditions studied: Post-cardiac Surgery, Hyperlactatemia
In brief
This is a single-center, observational study. Investigators aim to characterize the metabolism of lactate in children over the first forty-eight hours following cardiac surgery. Blood samples will be obtained up to 12 timepoints. Samples will be analyzed for concentration of pyruvate. Results will be compared to standard of care laboratory results for lactate and other direct and indirect measures of cardiac output.
Key facts
- Study ID
- NCT03025659
- Run by
- University of Florida
- People needed
- 43
- Starts
- 2017-05-28
- Expected to finish
- 2019-01-24
- Last updated by the study team
- 2020-03-23
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All immediately post-operative cardiac patients admitted to the pediatric cardiac intensive care unit (PCICU)
You may not qualify if…
- Lack of parental or patient consent, or patient assent when applicable, including non-English speakers and wards of the state
- Dosing weight less than 4 kg*
- Cardiac catheterization being the only operative procedure
- Severe hepatic dysfunction at any time during the hospital course
- Seizures during the study period
- Sepsis during the study period
- Need for extracorporeal membrane oxygenation or continuous renal replacement therapy
- Known congenital myopathy, ataxia, polyneuropathies or inborn errors of metabolism including congenital lactic acidosis and other mitochondrial disorders
- Primary hypoventilation
- Malignancies
- Fanconi syndrome
- Wernicke encephalopathy
Where it is running
- University of Florida Shands Children's Hospital — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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