Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids

Completed · Phase 1

Conditions studied: Glucocorticoids Toxicity, Glucose Intolerance

In brief

This study evaluates the effect of acute administration of oral prednisone in white blood cells counts and glucose tolerance and the relationship of these measures with changes in gene expression in healthy volunteers. White blood cells counts, glucose tolerance and gene expression will be study before and after prednisone administration.

Key facts

Study ID

NCT03023891

Run by

Vanderbilt University Medical Center

People needed

25

Starts

2017-02-15

Expected to finish

2019-12-31

Last updated by the study team

2020-06-04

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 45 years old (to exclude the effect of age on glucose tolerance);
• BMI between 20 and 25 kg/m2 (to exclude individuals that are likely to have impaired insulin response);
• Normal fasting glucose;
• Stable weight for three months before participation

You may not qualify if…

• BMI >25kg/m2;
• Fasting glucose ≥126 mg/dl
• Shift work or disordered sleep (to exclude individuals with alterations in the hypothalamus-adrenergic axis);
• Any diseases;
• Use of any medication regularly (including over-the-counter);
• Previous exposure to glucocorticoids (within the last year);
• Pregnancy

Where it is running

• Vanderbilt University Medical Center -CRC — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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