CSE v. Epidural for Postpartum Depression

Completed · Not applicable

Conditions studied: Depression, Postpartum, Labor Pain

In brief

The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms. Investigators will randomize women to the receipt of CSE or E during labor, after measuring baseline psychological, psychosocial, and psychophysical factors related to pain and depression. The immediate research goals are to understand whether the association between labor pain and PPD is modifiable through the use of tailored anesthetic techniques.

Key facts

Study ID

NCT03022526

Run by

Grace Lim, MD, MS

People needed

61

Starts

2017-01-01

Expected to finish

2019-12-31

Last updated by the study team

2020-08-19

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Nulliparous (no prior childbirth)
• Singleton gestation
• Third trimester
• Healthy pregnancy
• English proficiency (surveys validated in English)
• Planned vaginal delivery
• Planning to use labor epidural analgesia
• Term delivery (>/= 37.0 weeks)

You may not qualify if…

• Severe maternal disease
• Severe fetal disease
• Delivery not at term (delivery prior to 37.0 weeks)
• Contraindications to neuraxial anesthesia known at the time of enrollment
• Cesarean delivery WITHOUT labor
• Planning to list infant for adoption
• Did not receive epidural analgesia (either CSE or E) for labor

Where it is running

• Magee Womens Hospital of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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