VCRC Longitudinal Protocol for Aortitis
Completed
Conditions studied: Aortitis
In brief
The term 'aortitis' refers to inflammation of the aorta. Aortitis is known to occur in a variety of vasculitides and connective tissue diseases, such as giant cell arteritis (GCA), Takayasu arteritis (TAK), rheumatoid arthritis, and spondyloarthropathies, among others. This study will establish a longitudinal cohort for these diseases.
Key facts
- Study ID
- NCT03022331
- Run by
- University of Pennsylvania
- People needed
- 16
- Starts
- 2017-12-04
- Expected to finish
- 2019-09-01
- Last updated by the study team
- 2020-05-11
Who can join
Age: 5 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects will be included if they meet one of the following criteria:
- Previous or current microscopic evidence of aortitis (active or healed) on surgical specimen obtained during aortic resection
- Previous or current radiographic aortitis that could include circumferential aortic wall thickening of at least 3mm on CT or MRI or increased PET FDG uptake in the aorta at values equal to or greater than the liver, in absence of an alternative explanation for the radiographic findings.
- Exclusion
- Subjects already enrolled in one of the other VCRC longitudinal cohorts: 5502, 5503, 5504, 5505, and 5506.
- Inability of participants (or their guardians in the case of children) to give informed consent and to sign the consent form.
Where it is running
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Boston University — Boston, Massachusetts, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Cleveland Clinic Foundation — Cleveland, Ohio, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- University of Utah — Salt Lake City, Utah, United States
- University British Columbia/Mary Pack Arthritis Centre — Vancouver, British Columbia, Canada
- St. Joseph's Healthcare — Hamilton, Ontario, Canada
- University of Toronto, Mount Sinai Hospital — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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