Severe ARDS: Generating Evidence

Completed

Conditions studied: Acute Respiratory Distress Syndrome, Acute Respiratory Failure With Hypoxia, Acute Respiratory Failure

In brief

An assessment of early management of moderate-severe ARDS in the United States, including ventilator management and use of rescue therapy.

Key facts

Study ID

NCT03021824

Run by

Montefiore Medical Center

People needed

2400

Starts

2016-10-01

Expected to finish

2017-04-30

Last updated by the study team

2020-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Patients with acute respiratory failure requiring invasive mechanical ventilation via an endotracheal tube or tracheostomy with current or planned admission to the ICU
• Moderate-severe ARDS as defined by fulfillment of all of the following within 48 hours:
• Bilateral opacities detected on chest radiograph or CT, not fully explained by effusions, lung collapse, or nodules
• Respiratory failure not fully explained by cardiac failure or fluid overload
• PaO2/FiO2 ratio < 150 with a minimum of 5 cmH20 PEEP

You may not qualify if…

• There are no exclusion criteria.

Where it is running

• University of Arizona — Tucson, Arizona, United States
• Los Angeles County + University of Southern California Medical Center — Los Angeles, California, United States
• University of California, Los Angeles — Los Angeles, California, United States
• Mayo Clinic — Jacksonville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• University of Kentucky Medical Center — Lexington, Kentucky, United States
• Saint Agnes Hospital — Baltimore, Maryland, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Baystate Medical Center — Springfield, Massachusetts, United States
• University of Michigan Medical Center — Ann Arbor, Michigan, United States
• Saint Joseph Mercy Ann Arbor — Ypsilanti, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Regions Hospital — Saint Paul, Minnesota, United States
• Northwell Health — Manhasset, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• East Carolina University — Greenville, North Carolina, United States
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• Ohio State University Medical Center — Columbus, Ohio, United States
• Oregan Health and Science University Hospital — Portland, Oregon, United States
• Temple University Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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