Impact of Hemodynamic Ramp Test-Guided HVAD RPM and Medication Adjustments on Exercise Tolerance and Quality of Life

Completed · Not applicable

Conditions studied: Continous Flow Left Ventricular Device

In brief

The main purpose of this study is to compare Echo-guided testing to the Hemodynamic-Echo Ramp Tests to determine which method of testing provides better information for adjusting pump speed and medical treatment for Left Ventricular Assist Device (LVAD) patients. Better adjustments may provide better quality of life, exercise tolerance and reduced unwanted cardiac events over a 6-month period.

Key facts

Study ID

NCT03021239

Run by

University of Chicago

People needed

40

Starts

2016-03-01

Expected to finish

2019-04-01

Last updated by the study team

2019-04-10

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient older than 18 years
• Newly implanted HVAD
• HVAD support anticipated for at least 6 months
• Patient is ambulatory and discharged from hospital without inotropes
• Patient is between 1 and 3 months post implant
• Patient has not had a right heart catheterization since discharged from HVAD implantation hospitalization

You may not qualify if…

• The current HVAD is a replacement device
• Patients currently has Right Ventricle (RV) failure requiring home inotropes
• Inability to preformed right heart cath
• Inadequate echocardiographic windows

Where it is running

• UC San Diego Medical Center — San Diego, California, United States
• Stanford Medical Center — Stanford, California, United States
• Northwestern University — Chicago, Illinois, United States
• The University of Chicago — Chicago, Illinois, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• University of Washington School of Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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