IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty

Completed · Phase 4 · Has a placebo group

Conditions studied: Pain, Postoperative, Opioid Use

In brief

The purpose of this study is to determine how well two different methods of administrating Tylenol reduce pain and improve patient satisfaction after total hip replacement (THR) surgery. The methods of administration are orally, via a pill that is to be swallowed, and intravenously. Our aim is to determine whether oral or intravenous administration of Tylenol will reduce opioid consumption and opioid-related side effects after THR.

Key facts

Study ID

NCT03020966

Run by

Hospital for Special Surgery, New York

People needed

154

Starts

2017-02-16

Expected to finish

2019-06-16

Last updated by the study team

2021-08-10

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult
• Scheduled for an elective primary THA with a participating surgeon,
• Planned for Combined Spinal Epidural anesthesia (CSE) and Patient Controlled Epidural Analgesia (PCEA)
• English-speaking
• Patients that did not receive pre-operative opioids

You may not qualify if…

• Hepatic or renal insufficiency, as defined by abnormal readings on liver and kidney functioning tests.
• Hypersensitivity or contraindication to protocol medication
• Contraindication for CSE and PCEA
• Incapable to provide consent/answer questions in English
• Revision or urgent surgery
• Receiving Periarticular Injections
• History of opioid use
• Patients on disability or worker's compensation

Where it is running

• Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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