Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Stroke, Cerebrovascular Disorders, Nervous System Diseases, Brain Diseases, Cardiovascular Diseases, Vascular Diseases, Central Nervous System Diseases

In brief

The investigators ultimate goal is to personalize brain stimulation for stroke so outcomes of the upper limb can be maximized for each individual patient. Several groups including the investigators have recently theorized that personalizing stimulation so as to selectively stimulate iM1 in mild, and cPMd in patients with greater severity would help generalize benefits of stimulation. The investigator premise that variances in expressions of plasticity can explain how to best stratify patients for robust, personalized stimulation.

Key facts

Study ID

NCT03020433

Run by

The Cleveland Clinic

People needed

37

Starts

2016-03-01

Expected to finish

2019-12-01

Last updated by the study team

2020-07-16

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• greater than 21 years old
• more than 6 months from first, unilateral index stroke
• unilateral paresis of the upper limb indexed as greater than or equal to 20% slowness in functional reaching compared to non-paretic limb
• UEFM less than or equal to 61 out of 66.

You may not qualify if…

• subjects who cannot perform reaching with shoulder
• severe cognitive deficit (less than or equal to 24 on Mini-Mental State examination.
• contraindication to TMS or MRI including: seizures, ongoing use of certain neuro- or psycho-active medications, implants, or pacemaker.
• currently receiving outpatient therapy.

Where it is running

• Cleveland Clinic Foundation — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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