A Study of Lanabecestat (LY3314814) in Healthy Participants When Taken With Rosuvastatin

Completed · Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to evaluate the effect of lanabecestat on rosuvastatin. The amount of rosuvastatin in the blood will be compared, when taken alone, and then when taken with lanabecestat. The amount of lanabecestat that gets into the bloodstream will be measured. Information about any side effects that may occur will also be collected. Participants will be on study for 21 days with a follow-up at least 7 days afterwards. Screening will be undertaken within 45 days prior to enrollment.

Key facts

Study ID

NCT03019549

Run by

AstraZeneca

People needed

42

Starts

2017-01-12

Expected to finish

2017-05-22

Last updated by the study team

2019-11-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women not of childbearing potential may participate and include those who are:
• Infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy, or tubal ligation), congenital anomaly such as mullerian agenesis; or
• Postmenopausal - defined as women over 50 years of age with an intact uterus who have not taken hormones or oral contraceptives within 1 year, who have had either Spontaneous cessation of menses for at least 12 consecutive months, or 6 to 12 months of spontaneous amenorrhea with follicle-stimulating hormone level greater than (>)40 milli-international units per millilitre (mIU/mL) consistent with menopause
• Caucasian and may be of Hispanic ethnicity
• Body mass index (BMI) of 19 to 32 kilogram per meter square (kg/m²), inclusive, at the time of screening

You may not qualify if…

• Have a clinically significant abnormal blood pressure or heart rate (supine) as determined by the investigator

Where it is running

• Covance Clinical Research Inc — Daytona Beach, Florida, United States

Full record on ClinicalTrials.gov

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