The Sinonasal Cavity as a Reservoir for Upper Airway Bacterial Development

Completed

Conditions studied: Cystic Fibrosis

In brief

While the maternal-newborn exchange of airway microbiota is well-documented, no studies have examined within-subject relationships among the mouth, sinuses, nasopharynx and lungs and the relative abundance of bacterial taxa at those sites. Recent evidence suggests the oral cavity may serve as a reservoir for pathogens that translocate to non-oral locations; oral-associated microbes infect most other body sites as evidence by 16S sequencing. By using a combination of oral and throat swabs, together with nasal suction of mucus samples, the investigators will use metagenomic sequencing to characterize the composition of bacterial communities at each anatomical site. Beginning at birth, a time-series of swabs will be collected from each subject, and monitor changes in the development of microbiota over time. By doing so, our studies will illuminate airway trafficking of both beneficial and pathogenic microbes and may represent an essential pathophysiological step towards shifting the balance between airway health and disease.

Key facts

Study ID

NCT03016689

Run by

University of Minnesota

People needed

7

Starts

2017-05-31

Expected to finish

2019-09-12

Last updated by the study team

2026-02-20

Who can join

Age: 0 and older, up to 3. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of CF by sweat chloride test >60 mEq/L or by presence of two known CF genetic mutations
• Age 0-3 years
• Willingness to comply with study procedures
• Willingness of parent/guardian to provide written consent.

You may not qualify if…

• Presence of vasculitis or rheumatologic disorder

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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