Biomarkers as Predictors of Suicidal Risk in Adolescents
Completed
Conditions studied: Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
In brief
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk. We will utilize blood biomarker measurement and clinical risk factor scales to develop a tool to identify adolescents at risk for suicide earlier, which will allow clinicians to prescribe timely treatment and prevent suicide.
Key facts
- Study ID
- NCT03014518
- Run by
- The Cleveland Clinic
- People needed
- 80
- Starts
- 2016-12-01
- Expected to finish
- 2021-06-28
- Last updated by the study team
- 2021-07-16
Who can join
Age: 12 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Suicide Attempt Study Group:
- 12-18 years of age
- admitted to the Cleveland Clinic inpatient child and adolescent psychiatry unit after suicidal ideations or a suicide attempt
- Healthy Control Group:
- 12-18 years of age
- No history of suicide attempt
You may not qualify if…
- Suicide Attempt Study Group:
- History of autism spectrum disorder
- Non-verbal
- Moderate or severe intellectual disability (IQ<70 and patients in special education full-time)
- Schizophrenia or schizoaffective disorder diagnosis
- Current diagnosis of anorexia or bulimia
- History of generalized tonic-clonic epileptic seizures in last 3 months (If patient does not have a history of seizures, and generalized tonic-clonic seizure was clinically determined to be caused by patient's recent overdose attempt, patient can still be recruited for study if 24 hours has passed since last seizure)
- History of traumatic brain injury, brain tumor, or any major neurological disorder
- Delirium or mood disorder secondary to general medical condition
- Current infection, fever, antibiotic use in the last 2 weeks
- History of autoimmune or immunodeficiency diseases
- Current untreated major endocrine disorder
- Current pregnancy or delivery within the last month
- Diagnosed malnutrition
- Positive urine toxicology for benzodiazepines or opiates on admission
- Current substance use disorder diagnosis and referral for CD assessment upon discharge
- Current diagnosis of morbid obesity or a current BMI greater than 40 kg/m2
- Abnormal complete blood count (CBC)
- Healthy Control Group:
- History of any psychiatric diagnosis / treatment (behavioral diagnoses [ADD/ADHD/etc] are okay)
- History of suicidal ideation, behavior, or attempt
- Family history of suicide attempts
- Diagnosis of schizophrenia or bipolar disorder in parents or siblings
- History of autism spectrum disorder
- Moderate or severe intellectual disability (IQ<70 and patients in special education full-time)
Where it is running
- The Cleveland Clinic — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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