Diet Composition and Physical Inactivity on Insulin Sensitivity and β-cell Function

Completed · Not applicable

Conditions studied: Physical Inactivity, Dietary Protein

In brief

Physical inactivity results in reductions in glucose tolerance and less sensitivity to insulin. If this inactivity lasts long enough it can result in insulin resistance and type 2 diabetes. A high protein diet can reduce elevated glucose levels in individuals with type 2 diabetes. Thus the investigators are interested in establishing if during a period of inactivity if a diet modification can minimize the glucose changes normally observed with inactivity. The objective of this project is to determine if short-term high protein (HP) feeding protects against the changes in glucose levels normally observed with physical inactivity. The investigators will also examine measures of blood vessel function, blood lipid and blood pressure. Twelve subjects will complete two 10 day study periods of reduced physical activity and will be studied before and after each of these study periods. For their testing subjects will have the following measurements: postprandial glucose responses to a mixed meal, 24 h free living blood pressure control during acute physical inactivity, blood lipids, changes in body composition, changes in circadian rhythm using skin temperature (ibutton), measurement of aerobic capacity (VO2 max), blood vessel responsiveness (flow mediated dilation -FMD) and changes in free living glucose levels (continuous glucose monitoring system (CGMS). Subjects will complete two conditions (high protein -HP vs normal protein - NP diets) in a randomized cross-over design. In the inactive phase subjects will reduce there steps to \<5,000 steps/d while consuming either a HP or NP diet. Completion of the study will take 8-10 weeks.

Key facts

Study ID

NCT03013764

Run by

University of Missouri-Columbia

People needed

15

Starts

2015-10-01

Expected to finish

2017-09-30

Last updated by the study team

2018-10-15

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI <28 kg/m2
• No known cardiovascular, kidney, or liver disease.
• No history of surgery for weight loss and weight stable for prior 3 months (weight change < 3 kg).
• Physically active individual (90 minutes of primarily whole body aerobic physical activity <3 days per week and taking greater than 10,000 steps per day)
• Between 18-45 yr of age.
• Participants who consume on average less than 18% of total calories as protein

You may not qualify if…

• History of alcohol use (< 20 g/day for males and > 10 g/day for females)
• Smoker.
• BMI < 28 kg/m2
• Kidney or liver disease.
• Physically inactive (completing < 75 min of whole body aerobic activity <3 times per week or obtaining <10,000 steps/day)
• Pregnant or lactating
• <18 or >45 yr of age
• High protein consumers (>20% of total daily calories as protein)

Where it is running

• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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