Utility of Lung Clearance Index Score as a Noninvasive Marker of Deployment Lung Disease
Completed
Conditions studied: Bronchiolitis, Pneumonitis, Dyspnea
In brief
The purpose of this study is to learn more about new noninvasive ways of detecting lung disease in US Military personnel and people who worked as contractors during military operations in Iraq and Afghanistan. This study is looking at conducting a type of breathing test called the lung clearance index (LCI) test which is being investigated as a potential noninvasive way to detect the type of lung disease that may be seen in symptomatic deployers retuning from Iraq and Afghanistan.
Key facts
- Study ID
- NCT03012958
- Run by
- National Jewish Health
- People needed
- 73
- Starts
- 2014-07-01
- Expected to finish
- 2018-05-01
- Last updated by the study team
- 2021-01-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For the deployer group:
- presence of respiratory symptoms (cough, chest tightness, wheezing, shortness of breath or decreased exercise tolerance) following deployment
- history of deployment for Operation Iraqi Freedom, Operation Enduring Freedom or Operation New Dawn for greater than or equal to 6 weeks as either military personnel or a civilian contractor
- prior VATS biopsy-proven histologic abnormalities of small airways disease.
- For the control group:
- no history of pre-existing lung disease
- no respiratory illness in the four weeks preceding enrollment
You may not qualify if…
- For the deployer group:
- If on clinical evaluation they were found to have asthma, vocal cord dysfunction or other explanations for their respiratory symptoms and did not need to undergo surgical lung biopsy for diagnosis.
- unable to provide informed consent
- pregnant subjects
- For the control group:
- pre-existing lung disease
- unable to provide informed consent
- pregnant subjects
Where it is running
- National Jewish Health — Denver, Colorado, United States
Full record on ClinicalTrials.gov
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