Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk Mechanisms

Completed · Not applicable

Conditions studied: Depression

In brief

This study evaluates Interpersonal Therapy (IPT) in the treatment of depression among pregnant women with elevated depressive symptoms. Half of the women will be randomized to receive IPT, and the other half will get Treat As Usual, provided via behavioral health in the hospital.

Key facts

Study ID

NCT03011801

Run by

University of Illinois at Urbana-Champaign

People needed

234

Starts

2017-09-01

Expected to finish

2024-05-28

Last updated by the study team

2024-12-06

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Adult women (over 18 years of age)
• A singleton intrauterine pregnancy
• English speaking
• Elevated depressive symptoms based on screening with the Edinburgh Postnatal Depression Scale (EPDS) with score > 9

You may not qualify if…

• Bipolar disorder and psychosis based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-NP)
• Current psychotropic medication use or current CBT/IPT usage
• An HPA axis or an endocrine disorder
• Maternal substance use [assessed using maternal report and urine toxicology
• Corticosteroid medication use during this pregnancy
• Invitto fertilization
• Presence of cervical or uterine abnormalities

Where it is running

• University of Denver — Denver, Colorado, United States
• University of Illinois — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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