Omission of Intact Parathyroid Hormone Testing During Surgery in Treating Patients With Primary Hyperparathyroidism

Completed · Not applicable

Conditions studied: Parathyroid Gland Adenoma, Primary Hyperparathyroidism

In brief

This clinical trial studies the omission of intact parathyroid hormone testing during surgery in treating patients with primary hyperparathyroidism. Omission of intact parathyroid hormone testing during parathyroid gland removal may help patients with primary hyperparathyroidism to decrease their time under anesthesia, and decrease the overall time and cost of surgery.

Key facts

Study ID

NCT03011736

Run by

Roswell Park Cancer Institute

People needed

6

Starts

2016-05-12

Expected to finish

2018-12-24

Last updated by the study team

2021-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Positive 4 dimensional computed tomography (4D CT) for single gland (adenoma) primary hyperparathyroidism
• Preoperative serum calcium levels >= 10.9 mg/dL
• Preoperative parathyroid hormone (PTH) elevated beyond normal range or inappropriately high for associated calcium level
• Patient has no history of prior neck surgery or external radiation to neck for malignant conditions
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of =< 2
• Subject or legal representative must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure

You may not qualify if…

• Patient has recurrent hyperparathyroidism
• 4D CT positive for multiple gland disease
• Patient has inability to tolerate 4D CT scan (for example; contrast intravenous (IV) allergy, claustrophobia, renal disease)
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant or nursing female subjects; may be determined in the preoperative evaluation
• Unwilling or unable to follow protocol requirements
• Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo observational study (may also include preoperative testing results including electrocardiography [EKG], chest x-ray, or pulmonary function tests that preclude a wide excision in the operating room)

Where it is running

• Roswell Park Cancer Institute — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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