The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
Withdrawn before enrolling · Phase 1
Conditions studied: Cigarette Smoking Toxicity, Nicotine, Acute Cardiovascular Disease
In brief
The goal of this project is to evaluate the nicotine induced acute cardiovascular changes in E-Cigarette users and also study the mechanism involved particularly with vascular impairment.
Key facts
- Study ID
- NCT03010995
- Run by
- University of Louisville
- People needed
- 0
- Starts
- 2018-03-13
- Expected to finish
- 2018-07-24
- Last updated by the study team
- 2018-07-26
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participant will be currently healthy individuals, between 18 and 40 years of age.
- E-Cigarette users using E-Cigarette for at least 1 month and smoke ≤ 1 tobacco cigarette / day; non-smokers who used less than 100 tobacco cigarettes in their lifetime and are not active nicotine/tobacco or related product users
- Participants willing to abstain from vaping, smoking and tobacco for 12 hours prior to study.
- Do not meet any of the Exclusion criteria.
You may not qualify if…
- Unwilling or unable to provide informed consent.
- Participant that have: Diabetes, Hypertension HIV, hepatitis, liver disease (including fatty liver), anemia, unhealed wounds, active infection, febrile, anemia, organ transplant, renal replacement therapy, kidney disease or insufficiency, dialysis, active cancer of any type, and untreated thyroid disease, major injury or trauma.
- Body weight less than 100 pounds or BMI >40.
- Participants that are taking the following medications: estrogen, testosterone, anti TNF agents, cyclophosphamide, ketoconazole, methoxsalen, pilocarpine, Isoniazid, rifampicin certain biologics, or Procrit
- Participants that are currently using nicotine patches, nicotine gum or any form of nicotine-containing cessation device
- Pregnant or lactating women.
- Prisoners and other vulnerable populations.
- Anyone that PI thinks is unsafe to participate in the study.
Where it is running
- University of Louisville — Louisville, Kentucky, United States
Full record on ClinicalTrials.gov
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