IINB vs. QLB for Elective Open Inguinal Herniorrhaphy

Completed · Phase 2

Conditions studied: Nerve Block, Herniorrhaphy, Regional Anesthesia

In brief

Open inguinal herniorrhaphy is a common outpatient surgical procedure. Post-operative pain can be a significant hindrance to discharge from the post anesthesia care unit. Pain can be treated with opioid therapy, but the literature supports that these agents are known to create or exacerbate adverse effects and complications, including post-operative nausea and vomiting, hypoxia, and urinary retention. In contrast, analgesia provided by regional anesthesia results in a decreased risk of the aforementioned complications.1 Because of this, various regional anesthetic techniques have been developed to provide analgesia following open herniorrhaphy. One technique is a combined ilioinguinal and iliohypogastric nerve block (IINB), which has been shown to decrease the initial pain after inguinal herniorrhaphy.2 The quadratus lumborum block (QLB) is a newer regional anesthetic technique that we think could be as effective as IINB at providing pain control following open herniorrhaphy. Additionally, because local anesthetic injected during a QLB has the potential to spread cranially into the thoracic paravertebral space following its lumbar deposition it could lead to alleviation of both somatic and visceral pain.3 This might therefore improve the quality and or duration of analgesia as compared to the IINB. To the best of the author's knowledge there has been no investigation comparing the efficacy, with regards to post-operative pain management, between IINB and QLB.

Key facts

Study ID

NCT03007966

Run by

Wake Forest University Health Sciences

People needed

60

Starts

2017-01-30

Expected to finish

2018-02-17

Last updated by the study team

2019-11-18

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patient's scheduled for elective unilateral open inguinal hernia repair at WFUBMC.

You may not qualify if…

• The anesthesiologist performing the intraoperative anesthetic deems the patient inappropriate for general anesthesia.
• If the patient uses more than 40mg of Oxycodone equivalents per 24 hours or is on extended release opioid formulations.
• If there is a contraindication to the performance of a regional block
• Concomitant anticoagulation use
• Allergy to local anesthetic
• Infectious or dermatologic conditions in the area of block placement that would otherwise increase the risk of peripheral nerve blockade
• Patient refusal
• Pregnancy
• Institutionalized individuals
• Extremes of age: Age > 90 or < 18
• Non English speaking

Where it is running

• Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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