A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Ulcerative Colitis (UC)

In brief

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Key facts

Study ID

NCT03006068

Run by

AbbVie

People needed

950

Starts

2017-01-31

Expected to finish

2027-07-01

Last updated by the study team

2026-01-12

Who can join

Age: 16 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible
• Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met.
• If female, participant must meet the contraception criteria.
• Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit.
• Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234).
• Must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

You may not qualify if…

• For any reason participant is considered by the investigator to be an unsuitable candidate.
• Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug.
• Known hypersensitivity to upadacitinib or its excipients or had any adverse event (AE) during the preceding studies, that in the investigator's judgment makes the participant unsuitable for this study.
• Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated.
• Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol.
• Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study.
• Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234.
• History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.

Where it is running

• CB Flock Research Corporation /ID# 165986 — Mobile, Alabama, United States
• Delsol Research Management, Ll /Id# 170130 — Chandler, Arizona, United States
• Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886 — Mesa, Arizona, United States
• Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823 — Sun City, Arizona, United States
• Adobe Clinical Research LLC /ID# 155249 — Tucson, Arizona, United States
• Duplicate_University of Arizona /ID# 150568 — Tucson, Arizona, United States
• Citrus Valley Gastroenterology /ID# 151915 — Covina, California, United States
• Newport Huntington Medical Group /ID# 217006 — Huntington Beach, California, United States
• UC San Diego Health System /ID# 155187 — La Jolla, California, United States
• United Medical Doctors /ID# 207467 — Los Alamitos, California, United States
• TLC Clinical Research Inc /ID# 216830 — Los Angeles, California, United States
• Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082 — Los Angeles, California, United States
• Facey Medical Foundation /ID# 203135 — Mission Hills, California, United States
• United Medical Doctors - Murrieta /ID# 151213 — Murrieta, California, United States
• Ventura County Gastroenterology Medical Group /ID# 163417 — Oxnard, California, United States
• Inland Empire Clinical Trials, LLC /ID# 216163 — Rialto, California, United States
• San Diego Clinical Trials /ID# 212121 — San Diego, California, United States
• Medical Assoc Research Grp /ID# 169149 — San Diego, California, United States
• Univ of California San Francis /ID# 164583 — San Francisco, California, United States
• Delta Waves, Inc. /ID# 151727 — Colorado Springs, Colorado, United States
• South Denver Gastroenterology /ID# 151224 — Lone Tree, Colorado, United States
• Western States Clinical Res /ID# 158078 — Wheat Ridge, Colorado, United States
• Duplicate_Western Connecticut Medical Group /ID# 169211 — Danbury, Connecticut, United States
• Gastroenterology Center of Connecticut /ID# 150534 — Hamden, Connecticut, United States
• East View Medical Research, LLC /ID# 171184 — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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