Sodium Deposition in Soft Tissues of Patients with Kidney Disease
Recruiting now
Conditions studied: Haemodialysis Complication
In brief
Sodium (Na+) hemostasis is abnormal in CKD patients, and this element can be deposited in the skin, muscle, and skeleton - to cope with long term sodium loading. It is known that sodium stored in this non-osmotically active way, is profoundly inflammatory. Furthermore, inflammation has been associated with several uremic symptoms. The investigators will use novel Na+ MRI imaging to examine the Na+ deposition in the skin, muscle, and skeleton of five groups:1) chronic in-center hemodialysis patients, 2) chronic peritoneal dialysis patients, 3) adult and paediatric patients with CKD stage 1-5 and 4) heart failure patients with and without renal dysfunction 5) sex and age-matched healthy adult and paediatric controls. Additionally, they will investigate the association between sodium deposition in these tissues with uremic symptomatology and biochemical markers of metabolism.
Key facts
- Study ID
- NCT03004547
- Run by
- Chris McIntyre
- People needed
- 400
- Starts
- 2018-03-05
- Expected to finish
- 2026-02-28
- Last updated by the study team
- 2025-02-12
Who can join
Age: 6 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age greater than or equal to 6 years
- For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
- For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis
- For heart failure patients: with or without renal dysfunction
- For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema
- For subsequent visits (must meet 1 of the below indicators):
- Change in dialysis prescription
- Change in renal replacement therapy modality
- Change in medication
- Parathyroidectomy
- Intervention added to or removed from dialysis (i.e. such as but not limited exercise, cooling, and ischemic preconditioning)
You may not qualify if…
- Pregnant, breastfeeding or intending pregnancy
- Unable to give consent or understand written information
- Contraindication to MRI study
Where it is running
- LHSC Regional Renal Care Program — London, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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