Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Recruiting now

Conditions studied: Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis

In brief

Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.

Key facts

Study ID

NCT03004326

Run by

Peter Merkel

People needed

50

Starts

2017-01-01

Expected to finish

2028-12-01

Last updated by the study team

2026-01-22

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
• Have a suspected or confirmed diagnosis of:
• Cryoglobulinemic vasculitis (CV)
• Drug-induced vasculitis
• Eosinophilic granulomatosis with polyangiitis (EGPA)
• IgA vasculitis
• Isolated cutaneous vasculitis
• Granulomatosis with polyangiitis (GPA)
• Microscopic polyangiitis (MPA)
• Polyarteritis nodosa (PAN)
• Urticarial vasculitis
• Be willing and able to provide written informed consent (or assent for those under

You may not qualify if…

• You are less than five years old
• Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
• You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
• You have an uncontrolled disease that could prevent you from completing the study procedures
• You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study
• You are pregnant or nursing
• You are not able to provide informed consent

Where it is running

• University of Toronto Mount Sinai Hospital — Toronto, Ontario, Canada (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• University of Virginia — Charlottesville, Virginia, United States (enrolling)
• St. Joseph's Healthcare — Hamilton, Ontario, Canada (enrolling)
• Oregon Health & Science University — Portland, Oregon, United States
• University of California, Los Angeles — Los Angeles, California, United States
• University of Utah — Salt Lake City, Utah, United States
• Boston University School of Medicine — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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