Clinical Importance of Glucose Regulation in Relapsing MS
Status unconfirmed
Conditions studied: Relapsing Remitting Multiple Sclerosis, Clinically Isolated Syndrome
In brief
The purpose of this study is to assess the relationship of blood glucose levels in persons with Multiple Sclerosis (MS) who have experienced a relapse and will be receiving intravenous steroids for the relapse, to their recovery from the relapse. Steroid exposure commonly leads to elevated serum blood glucose, however, standardized monitoring of blood glucose levels in the outpatient setting is not common. The clinical impact of any associated elevated blood glucose during steroid administration is unknown. We hypothesize that the blood glucose response to steroid treatment is clinically relevant to the MS-relapse recovery.
Key facts
- Study ID
- NCT03004079
- Run by
- University of Virginia
- People needed
- 160
- Starts
- 2016-10-01
- Expected to finish
- 2020-09-01
- Last updated by the study team
- 2018-11-07
Who can join
Age: 18 and older, up to 59. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ability to provide informed consent
- Age 18 -59 years (inclusive)
- Ability to walk continuously for 6 minutes (per patient report)
- Clinically Isolated Syndrome (CIS) or Relapsing Remitting MS (RRMS) confirmed diagnosis by McDonald 2010 criteria
- Current MS relapse with objective findings on exam
- Relapse symptom onset within 2-weeks of screening
- Functional System Scores obtainable from a clinic visit within 6 months of the relapse assessment visit
- EDSS < 6.5 at time of screening visit
- Inpatient, outpatient, emergency department, or inpatient observation status
You may not qualify if…
- Prior steroid exposure within 90 days of enrollment
- HgA1c ≥ 6.5 at baseline screening
- Evidence of concurrent infection
- Known contraindications to IV steroid treatment
- History of diabetes mellitus ( type 1 or 2) or severe hypertension
- Use of any glucose-regulating medications
- Pregnancy or current use of hormone replacement therapy
Where it is running
- University of Virginia — Charlottesville, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.