Nutrient Sensing & Signaling in Aging Muscle

Completed · Not applicable

Conditions studied: Nutrient Sensing

In brief

This research seeks to better understand how cellular and molecular bases of changes associated with aging contribute to decreased function and increased incidence of disease. Specific mechanism in muscle responsible for anabolic resistance - a key component of sarcopenia and frailty - will be identified. The proposed research is relevant to public health because the discovery of new targets for interventions and novel therapeutics to improve muscle strength and function, prevent falls, and reduce physical dependency will improve the healthspan and quality of life in older adults by improving their physical function and ability to remain independent and healthy for a longer period of time.

Key facts

Study ID

NCT02999802

Run by

The University of Texas Medical Branch, Galveston

People needed

19

Starts

2015-10-01

Expected to finish

2016-12-21

Last updated by the study team

2018-06-13

Who can join

Age: 65 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 65-80 yrs
• Stable body weight for at least 1 year
• Ability to sign consent form:

You may not qualify if…

• Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
• Physical dependence or frailty (impairment in the Activities of Daily Living (ADL), history of falls (>2/year), or >5% weight loss in the past year)
• Significant heart, liver, kidney, blood, or respiratory disease
• Peripheral vascular disease
• Diabetes mellitus or other untreated endocrine disease
• Active cancer
• Acute infectious disease or history of chronic infections
• Recent (within 3 months) treatment with anabolic steroids, or prolonged systemic corticosteroids.
• Alcohol or drug abuse
• Tobacco use (smoking or chewing)
• Malnutrition (BMI < 18.5 kg/sq meter)
• Obesity (BMI > 30 kg/sq meter)

Where it is running

• UTMB — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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