Population Pharmacokinetics of Anti-infectives in Hospitalized Patients

Recruiting now

Conditions studied: Patient Receiving Anti-infectives Whatever Disease

In brief

In case of sepsis, the therapeutic success is strongly influenced by the choice of anti-infectives (AI) in terms of spectrum, dosage and administration schedule. It is therefore critical to achieve adequate AI concentration as quickly as possible. This protocol aims to define a common framework to studies conducted jointly by the Antimicrobial Stewardship Tea, the Pharmacology department of Cochin hospital and within the APHP Centre hospital group for various AI in a range of specific study populations (intensive care unit patients, neutropenic patients…). These studies will use mathematical modeling methodologies to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of different AI including PK/PD targets or any other biological compartment. The effects of covariates on PK and PD parameters will be investigated to better explain the between-subject variability (BSV) and to ultimately suggest individualized dosage regimens.

Key facts

Study ID

NCT02998411

Run by

Assistance Publique - Hôpitaux de Paris

People needed

60

Starts

2016-12-01

Expected to finish

2028-12-01

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Every adult hospitalized in Cochin hospital, receiving an AI and who require at least one AI concentration measurement or any other biological compartment in the Cochin department of pharmacology

You may not qualify if…

• Patient having notified to the physician the refusal for data recovery

Where it is running

• Cochin Hospital — Paris, Paris, France (enrolling)

Full record on ClinicalTrials.gov

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